Microcontact Printing for Precise Control of Nerve Cell Growth in Culture


Wheeler BC, Corey JM, Brewer GJ, Branch DW


Journal of Biomechanical Engineering

Publication Date



Microcontact printing, facilitated by silane linker chemistry and high-relief stamps, creates precise patterns of proteins, which in turn control growth of hippocampal neurons in culture. This additive, multi-mask technique permits several different molecules to be patterned on the same substrate. The covalent linker technology permits relatively long-term (two-week) compliance of neurons to the stamped pattern against a polyethylene glycol background. When polylysine was stamped adjacent to a laminin/polylysine mixture, neural somata and dendrites preferred the polylysine while axons prefer the mixture or the border between the two.

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Date added: 2012-10-11 08:59:30 | Last time updated: 2012-10-11 06:59:30 | Viewed: 1068 times

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