Physical Cues of Biomaterials Guide Stem Cell Differentiation Fate

Abstract

1. Introduction 2. Effect of Elasticity of Cell Culture Materials on Stem Cell Differentiation 2.1. Elasticity of Substrate Directs Stem Cell Differentiation Fate in 2-D Culture 2.2. Pluripotent Maintenance of ESCs, iPSCs, and MSCs on Soft Culture Substrate 2.3. Mechanism of Regulation of Stem Cell Differentiation Fate by ECM and Substrate Elasticity in 2-D Culture 2.4. Elasticity of Substrate Directs Stem Cell Differentiation Fate in 3-D Culture 2.5. Results Contradictory to Engler’s Research in 2-D Culture 2.6. Results Contradictory to Engler’s Research in 3-D Culture 3. Effect of Topography of Cell Culture Materials on Stem Cell Differentiation 3.1. Preparation of Micro- and Nanopatterned Surfaces 3.2. Adipogenic and Osteogenic Stem Cell Differentiation on Micropatterned Surfaces 3.3. Chondrogenic, Myogenic, and Hepatic Stem Cell Differentiation on Micropatterned Surfaces 3.4. Neural Stem Cell Differentiation on Micropatterned Surfaces 3.5. Stem Cell Differentiation on Nanofiber Surfaces 3.5.1. Stem Cell Differentiation on Nanofibers Formed by Self-Assembly of Amphiphile Peptides 3.5.2. Stem Cell Differentiation on Nanofibers Prepared by Electrospinning 3.5.3. Stem Cell Differentiation on Nanofibers Prepared Using Phase Separation 4. Conclusion

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Physical Cues of Biomaterials Guide Stem Cell Differentiation Fate